The male patient who was confirmed with the monkeypox virus has escaped from the May Pen Hospital in Clarendon, where he had been placed in isolation pending his recovery.
A statement from the Dr Christopher Tufton-led Health and Wellness Ministry on Saturday confirmed the development.
Reports are that sometime after 12:00 pm Saturday, the patient left through a bathroom window of the facility and had a car waiting.
The police have been called in and are investigating.
Anyone with information about the whereabouts of the patient is being urged to contact the police.
The man had presented to the public health system on July, having arrived in Jamaica some five days earlier from the United Kingdom.
